Ĭortisol is the final product of the hypothalamic–pituitary–adrenal axis (HPA) and is a primary stress hormone that acts via glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs), both of which are present in cardiomyocyte nuclei.
However, these neurohormonal changes may have deleterious effects if their activity is long enough to cause an increase in sensitivity to catecholamines and an increase in the mineralocorticoid receptors present in the myocardium. A cascade of events during the early phase of an AMI activates the neurohormonal system in an effort to preserve circulatory homeostasis. Patients with acute myocardial infarction (AMI) experience both physical and psychological stress, accompanied by its physiological manifestations. Conclusion: SNPs of the NR3C2 gene appear to correlate with better ventricular remodeling and a reduced rate of arrhythmias post-AMI, possibly by limiting the deleterious effects of cortisol on cardiomyocytes. The rs5522 TT genotype was associated with a higher frequency of arrhythmias, while the presence of at least one rs5522 C allele was associated with a lower risk of arrhythmias. Results: The rs2070950 GG genotype and rs4635799 TT genotype were most common in patients who had LV end-diastolic volume increase < 20% and the same or increased LV ejection fraction, indicating a possible protective effect of these SNPs. A total of 127 AMI patients underwent transthoracic echocardiography follow-up after 72 h and 6 months. Methods: A cohort of 301 AMI patients who underwent revascularization was included.
Objective: To study the impact of the NR3C2 rs2070950, rs4635799 and rs5522 gene polymorphisms on left ventricular (LV) remodeling, rhythm and conduction disorders in AMI patients. Prior studies reported an association between the presence of NR3C2 single-nucleotide polymorphisms (SNPs) and an increased cortisol production during a stress response such as acute myocardial infarction (AMI), which may lead to adverse cardiac remodeling.
Three years of experience teaching undergraduate courses in stagecraft.Background: The NR3C2 gene encodes the mineralocorticoid receptor, which is present on cardiomyocytes. Rigging, Sewing: Drops, Sewing: Drop Repair, Sewing: Curtains, Sewing: Curtain Repair, SewingĮxperienced theatrical carpenter, scenic painter, and projection technician with masters degree in scenic and media design. Welding, Drop Painting, Upholstery, Isadora Scenic Designer, Projections Designer, Properties Master, Assistant Scenic Designer, Assistant Projections Designer, Properties Designer, Paint Charge, Assistant Technical Director, Technical Director, Properties Assistant, Scenic Artist, Master Carpenter, Properties Carpenter, Projections Operator, Carpenter, Video Designer, Video Technician, Stagehand, Video Operatorĭrafting, Color Mixing, Faux Finishes, Foam Carving, Props Shopping, Teaching: Undergrad, qLab, Dataton WATCHOUT, qLab, VectorWorks, Inventory Management, Rental Management, Digital Image Editing, Crafts, After Effects, Teaching: Stagecraft, Light Upholstery
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